Indication name: Familial Amyloid Polyneuropathy
(FAP)
Familial amyloid polyneuropathy (FAP) –
Market outlook, Epidemiology, Market Forecast and Competitive Landscape Report
– 2019 To 2030 (Markets covered: US, Germany, France, Spain, United Kingdom,
Italy, Japan & China).
Familial amyloid polyneuropathy (FAP) or
transthyretin (TTR) amyloid polyneuropathy is a progressive sensorimotor and
autonomic neuropathy of adulthood onset. FAP is transmitted as an autosomal
dominant trait and is caused by mutations in the TTR gene (18q12.1). The most
common variant is the TTR Val30Met substitution for which several endemic foci
have been identified most notably from Portugal, Japan and Sweden.
Epidemiology- According to literature
review and Thelansis estimation, It occurs in approximately one in 5,000 to
10,000 individuals in the United States and accounts for about 0.5% of all
cases of colorectal cancer. According to national registries, familial
adenomatous polyposis occurs in 2.29-3.2 per 100,000 individuals.
Competitive landscape of Familial
Amyloid Polyneuropathy (FAP) includes country specific approved as well as
pipeline therapies. Any asset/ product specific designation or review and
Accelerated Approval are being tracked and supplemented with analyst
commentary.
KOLs insights of Familial Amyloid
Polyneuropathy (FAP) across 8 MM market from center of Excellence/ Public/
Private hospitals participated in the study. Insights around current treatment
landscape, epidemiology, clinical characteristics, future treatment paradigm
and Unmet needs.
Familial Amyloid Polyneuropathy (FAP)
Market Forecast: Patient Based Forecast Model (MS. Excel Based Automated
Dashboard) which Data Inputs with sourcing, Market Event and Product Event,
Country specific Forecast Model, Market uptake and patient share uptake,
Attribute Analysis, Analog Analysis, Disease burden and pricing scenario,
Summary and Insights.
S. No Asset Company Partner Phase
1
Celebrex Pfizer Inc. Astellas
Withdrawn from Market
2
ALFA S.L.A. Pharma AG N/A
III
3
CPP-1X/Sulindac
Mallinckrodt plc Zeria;
Cancer Prevention III
4
Tremfya Johnson &
Johnson MorphoSys; Otsuka I
5
CPP-1X Cancer Prevention
Pharmaceuticals, Inc. N/A Preclinical
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